The Complexes of Antibiotics with Trace Metals

The term antibiotics [Gr. anti against, bios life] refers to a group of organic natural chemical compounds produced by such microorganisms as: bacteria, actinobacteria, warious types of fungi and some plants and animal cells. Many substances isolated from these organisms are synthesized on an industrial scale as a whole (of synthetic origin, called chemiotherapeutics) or in part (of semisynthetic origin), [16]. The products of metabolism of actinobacteria constitute about 90% of natural antibiotics produced on an industrial scale [5]. The research into moulds has enabled the acquisition and consequently the synthesis and modification of the acquired compounds although their role in the life of microorganisms has not been explained [5]. From the medical point of view some of the most important metabolites secreted by the Penicilium chrysogenum Thom mould are penicillin G. and griseofulvin. Yet many other metabolites also have a wide range of action: antiseptic against Staphylococcus aureus, decomposing carbohydrates, oxidizing decanes, undecanes and hexadecanes from petroleum. The Acremonium strictum W.Gams mould